Although the implication of our results on the health of the laboratory animal workers we studied is unknown, our study is important because it enables comparison of worker tasks with their allergen exposure levels in an animal laboratory setting. The resulting baseline data can help evaluate facilities’ ongoing efforts to minimize worker exposure to allergens and establish acceptable exposure standards. Future research might include investigating the allergens produced by other animal species, the allergen content of the beddings, measurements behind respiratory protection, studies of dermal exposure, and ongoing exposure surveillance. Another direction is to assess the exposure of researchers, who may have less intense contact with the animals than do the husbandry staff but who contact animals under less controlled conditions and with fewer exposure control measures in place.
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Platts AnimalBedding Retweeted RABDF
Making the difference. Platts Animal Bedding is a market-leading UK manufacturer and supplier of quality animal bedding, based in North Wales. We offer a wide selection of bedding for dairy, equine, poultry & small pets We deliver our products to farmers across . During the time of our research, facility 1 housed 460 mouse cages (3 to 5 mice per cage; total, 1380 to 2300 mice), 26 rat cages (2 rats per cage; total, 52 rats), 5 to 6 rabbits, and 3 swine each week. Facility 2 housed 7 cats, 296 mouse cages (3 to 5 mice per cage; total, 888 to 1480 mice), and 237 rat cages (2 rats per cage; 474 rats). All mice were housed in isolation caging (MicroVent, Allentown, Allentown, NJ) on a ventilated rack with HEPA airflow. The ventilation units supplying these cages provided 60 air changes hourly and are serviced and certified annually. Whereas all mice were housed in these cage systems, all rabbits, cats, and rats were housed in static open-air cages. In addition, the ventilation in each holding room was supposed to have provided an air exchange of 10 to 15 air changes hourly, but this exchange rate was not verified during data collection. Cages were changed at least once weekly for mice, twice weekly for rats, and thrice weekly for rabbits. Facility 1 used corncob bedding, and facility 2 used hardwood chips and paper chips (AlphaDry, Shepherd Specialty Papers, Kalamazoo, MI) for rats after surgery and hardwood chips and corncob bedding for other animals. In the animal housing rooms, cages were opened for changing and animal handling within an animal transfer station (ATS5, Allentown) that was equipped with HEPA filter that is 99.99% efficient at filtering particles of 0.3 µm and smaller when placed under the hood. These change stations are serviced and certified annually. Not all rooms at facility 1 had animal transfer stations, whereas all rooms at facility 2 had them. Dirty cages were transferred to the wash room, emptied into a cage-dumping station (facility 1: model 3B, Viking Medical, Medford Lakes, NJ; facility 2: BioBubble Bedding Disposal Unit, Clean Room, Ft Collins, CO). The dumping stations were equipped with a HEPA-filtered hood vent and trash can underneath and were serviced and certified annually.Exposure to rodent allergens can be reduced in many ways, including through the use of engineering and administrative controls and personal protective equipment., Several studies have measured the airborne urinary allergens at fixed locations in animal rooms., Fixed-location sampling studies have examined the effects of caging systems,,,,, bedding characteristics, and room air flow and relative humidity in reducing urinary allergens at the room level. One study demonstrated the effectiveness of personal protective equipment though application of innovative personal sampling methods that place sampling media in the nostril, behind a respirator.Two female Hartley guinea pigs (Charles River Laboratories, Kingston, NY) were certified by the vendor to be free of: Sendai virus, pneumonia virus of mice, reovirus, lymphocytic choriomeningitis virus, E. cuniculi, guinea pig adenovirus, Bordetella bronchiseptica, Helicobacter spp., Streptococcus zooepidemicus, S. moniliformis, S. pneumoniae, C. piliforme, Mycoplasma pulmonis, and all endo- and ectoparasites. Guinea pigs were housed in a different room but in the same vivarium as the rabbits. Guinea pigs were pair-housed and maintained on contact hardwood bedding (Beta-chip, Northeastern Products, Warrensburg, NY) changed twice weekly, fed commercial guinea pig diet (Guinea Pig Diet 7006, Harlan Teklad), and provided with polyvinyl chloride pipes to hide in. Animals were maintained according to the recommendations in the Guide for the Care and Use of Laboratory Animals; the University of Illinois–Chicago's Animal Care Committee approved all experimental animal procedures.